The Fox Cities has identified five major industry clusters of prominence in the metropolitan area. These industry clusters represent the economic drivers of the region and have the critical mass of manufacturers, supplies and vendors to make these cluster thrive in the Fox Cities.

The prominent industry clusters are:

- Specialty and Converted Paper and Plastics
- Printing and Publishing
- Commercial and Industrial Machinery and Equipment
- Specialty Food Products and Packaging
- Transportation, Security, and Related Devices